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Dopexamine and dopamine in the prevention of low gastric mucosal pH following cardiopulmonary by‐pass
Author(s) -
GARDEBACK M.,
SETTERCREN G.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04231.x
Subject(s) - medicine , cardiopulmonary bypass , anesthesia , dopamine , saline , artery , pco2
The effect of low‐dose dopexamine and dopamine on gastric intramucosal pH (pH i ) during cardiac surgery and 16 hours postoperatively was studied in 35 adult patients (coronary artery bypass grafting and/or valve replacement). The patients were assigned randomly to treatment groups with either dopexamine 1 μg. kg ‐1 .min ‐1 (n=12), dopamine 2.5 μg. kg ‐1 .min ‐1 (n=11) or to a control group (n=12). The infusions were started after induction of anesthesia and were continued until 16 hours after CPB. pH i and arterial pH (pH a ) did not differ between groups and remained unchanged during cardiopulmonary by‐pass and for the first four postoperative hours. Both the carbon dioxide tension of arterial blood (P a CO 2 ) and of the saline in the tonometer (P ton CO 2 ) changed in parallel with a decrease during CPB and an increase after CPB and surgery with maximal values 12 hours after termination of CPB. A significant correlation was noted between pH i and pH a and between arterial and tonometric PCO 2 . It is concluded that low dose dopexamine and dopamine have no influence on pH i during and after cardiac surgery. The observed changes in pH i and P ton CO 2 were due to changes in pH a and in P a CO 2 and not a sign of gastric mucosal ischemia