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A porcine model for evaluation of cerebral haemodynamics and metabolism during increased intracranial pressure
Author(s) -
Nilsson F.,
ÅKeson J.,
Messeter K.,
Ryding E.,
Rosén I.,
Nordström C.H.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04179.x
Subject(s) - medicine , intracranial pressure , hemodynamics , cerebrovascular circulation , cardiology , anesthesia , cerebral blood flow
In patients with severe head injuries raised intracranial pressure (ICP) constitutes the most important cause of mortality. Several new therapies for increased ICP have recently been suggested and it is of importance to study the physiological effects of these treatments in animal experiments during steady state conditions. A porcine model for evaluation of cerebral haemodynamics and metabolism during increased ICP is presented. Intracranial hypertension was induced by inflation of two tonometric gastric balloons placed extradurally covering a major part of the parietooccipital region bilaterally. The distribution of the blood flow supplied by the carotid artery used for the cerebral blood flow (CBF) measurements was studied by intraarlerial (i.a.) injection of 99m Tc‐HMPAO. The measurements showed that following ligation of the external carotid and the occipital artery no accumulation of tracer substance occurred in extracranial tissues during normal or increased ICP. Cerebral physiological variables (CBF, Cavo 2 , and ICP) were measured 5, 20 and 60 rnin after induction of intracranial hypertension. The results confirm that the experimental situation gives a reproducible increase in ICP (25–28 mm Hg) and that the physiological variables remain stable during the period of intracranial hypertension. We conclude that the model simulates the effects of an acute intracranial focal mass and is well suited for the evaluation of different pharmacological therapies of increased ICP.