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Comparison of induction time and characteristics between sevoflurane and sevoflurane / nitrous oxide
Author(s) -
Yurino M.,
Kmura H.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04077.x
Subject(s) - nitrous oxide , sevoflurane , enflurane , medicine , laryngospasm , anesthesia , oxygen , inhalation , halothane , chemistry , airway , organic chemistry
A previous investigation using nitrous oxide with 5% enflurane (3.8 MAC) for single breath induction produced a stage of excitement which may be related to the difference in blood/gas coefficient solubility of these agents. The closer blood/gas solubility coefficient of sevoflurane and nitrous oxide may eliminate this phenomenon. We therefore evaluated 40 volunteers in a randomized study using 7.5% sevoflurane (3.7 MAC) in oxygen (n=21) or sevoflurane with nitrous oxide (n=19) using a single breath induction technique. Sevoflurane in nitrous oxide and oxygen reduced induction time by 15% compared to sevoflurane in oxygen alone (41 ±16 and 48±16 sec (s.d.), respectively). This was, however, not statistically significant. There were scarcely induction‐related complications, such as coughing, laryngospasm, breath‐holding, movements of a limb and excessive salivation, in either group. Thus, the addition of nitrous oxide neither increased the number of complications, nor the speed of induction.