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Does colloid‐induced plasma hyperviscosity in haemodilution jeopardize perfusion and oxygenation of vital organs?
Author(s) -
Krieter H.,
Brückner U. B.,
Kefalianakis F.,
Messmer K.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04050.x
Subject(s) - hyperviscosity , medicine , perfusion , hematocrit , blood viscosity , oxygenation , blood volume , dextran , skeletal muscle , cardiac output , oncotic pressure , anesthesia , hemodynamics , chemistry , biochemistry , albumin
Background and Methods . The infusion of dextran solutions is associated with haemodilution and, under some conditions, with a slight increase in plasma viscosity. To clarify the compound effects of simultaneous haemodilution and plasma viscosity increases on macro‐ and microhaemodynamics, we investigated the changes in arterial perfusion (radiolabelled microspheres, 15 μrn Ø) and oxygenation (tissue Po 2 ) of vital organs using an animal model of plasma hyperviscosity. In nine splenectomized beagles plasma viscosity was increased step by step from 1.06 (baseline) to 2.14, and 2.99 mPas by infusion of small amounts (4% of total blood volume) of an ultra‐high‐molecular‐weight dextran (50% w/v, mw: 500,000). Results . Despite the significant increase in plasma viscosity, cardiac output as well as specific organ blood flows in heart, brain, liver, and muscle rose steadily with each step of viscosity, while the haematocrit declined from 0.31 to 0.24 and 0.20, respectively. Medians of tissue Po 2 in liver peaked at a viscosity of 2 mPa.s and returned to baseline values at 3 mPa.s, whereas in non‐working skeletal muscle Po 2 values were maximal at 3 mPa.s. Conclusion . These results indicate that the impact of plasma viscosity on the rheological properties of whole blood is completely offset by die concomitant reduction of haematocrit. Thus, the comparatively minor changes in plasma viscosity observed after prolonged use of clinical dextrans and other colloids in no way compromise the perfusion and oxygenation of vital organs.