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Interstitial fluid accumulation does not influence oxygen uptake in the rabbit small intestine
Author(s) -
ØStgaard G.,
Reed R. K.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04037.x
Subject(s) - medicine , superior mesenteric artery , extracellular fluid , resuscitation , small intestine , oxygen , saline , anesthesia , interstitial fluid , base excess , vein , extracellular , biochemistry , chemistry , organic chemistry
Crystalloid resuscitation increases interstitial fluid volume. Intestinal ischemia and impaired barrier function may contribute to the precipitation of multiple organ failure. Accordingly, the intestine was chosen as target organ to test whether interstitial oedema impairs oxygen extraction by the tissue. The portal vein in anaesthetized rabbits was partially obstructed for 30 min along with an intravenous infusion of 0.9% saline 60–90 ml kg ‐1 (oedema group, n = 7). Total water content of the small intestine increased from 3.4 ml g ‐1 dry weight in control (n = 8) to 3.9 ml g ‐1 in the oedema group ( P = 0.049). Small intestinal O 2 uptake was calculated from the arteriovenous O 2 content and electromagnetic flow measurements in the superior mesenteric artery. Mesenteric flow was reduced stepwise by a snare occluder around the artery. Intestinal oxygen‐ation was monitored indirectly as well, by means of mesenteric venous lactate, arterial base excess and by mucosal pH (pH i ) assessed tonometrically. The oxygen extraction ratios were similar in the oedema and control group at similar oxygen supplies. After a 45 min flow reduction to 15% of baseline mesenteric venous lactate and pH i did not differ between the groups. pH; averaged 7.31 and fell to 6.74. Below an intestinal O 2 uptake of 2.5 ml min ‐1 , pH i correlated somewhat better with O 2 uptake (r=0.66) than did arterial base excess (r=0.50). The results indicate that acute elevation of extracellular volume to the extent in the present study, does not impede oxygen uptake in the gut.