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Effects of propofol and thiopentone on polymorphonuclear leukocyte functions in vitro
Author(s) -
SKOUTELIS A.,
LIANOU P.,
PAPAGEORGIOU E.,
KOKKINIS K.,
ALEXOPOULOS K.,
BASSARIS H.
Publication year - 1994
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1994.tb04018.x
Subject(s) - propofol , chemotaxis , phagocytosis , medicine , in vitro , neutrophile , pharmacology , polymorphonuclear leukocyte , granulocyte , immunology , function (biology) , anesthesia , inflammation , biochemistry , microbiology and biotechnology , biology , receptor
Anaesthetic agents may impair host defense mechanisms including polymorphonuclear leukocyte (PMNL) function. We have studied the effects of thiopentone and propofol in low (thiopentone 10 mg/L, propofol 2 mg/1) and high (thiopentone 40 mg/L, propofol 6 mg/L) clinically relevant concentrations on PMNL adherence, chemotaxis, phagocytosis and killing in vitro. The results demonstrated that thiopentone in both concentrations significantly decreases all PMNL functions tested and had a direct influence on the PMNLs in terms of their chemotactic response. In contrast, propofol decreases significantly only PMNL chemotaxis but not adherence, phagocytosis and killing. The effect of propofol was not attributable to the lipid carrier vehicle, as Intralipid with same formulation had no effect on PMNL function.