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Effects of metabolic pH–alterations on cerebral blood flow and oxygen uptake following E. coli endotoxin in dogs
Author(s) -
WESTERLIND A.,
LARSSON L. E.,
HÄGGENDAL J.,
EKSTRÖM–JODAL B.
Publication year - 1994
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1994.tb03854.x
Subject(s) - cerebral blood flow , sodium bicarbonate , bicarbonate , medicine , cerebrospinal fluid , metabolic acidosis , oxygen , sodium , metabolism , vasodilation , endocrinology , anesthesia , chemistry , organic chemistry
The aim of the present study was to investigate if metabolic pH–alterations have an influence on cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRo 2 ) after an injection of E. coli endotoxin. Following endotoxin in dogs with normal pH a decreased CBF and an increased CMRo 2 have earlier been found. Thirteen anaesthetized dogs were subjected to metabolic pH–variations in blood by infusion of hydrochloric acid or sodium bicarbonate. Ten dogs received E. coli endotoxin in a dose of 1 mg kg“‘ bodyweight. CBF, CMRo 2 and noradrenaline and adrenaline concentrations in blood and cerebrospinal fluid were measured repeatedly during normoxia and normocarbia. Measurements before endotoxin served as controls, together with three additional animals, where endotoxin was never given. In control measurements pH showed no influence on the variables studied. After endotoxin CBF, CMRo 2 and noradrenaline in cerebrospinal fluid increased with decreasing arterial blood pH. The influence exerted by metabolic pH alterations in blood after endotoxin may be explained by hydrogen ions and monoamines passing over a blood–brain barrier (BBB), damaged by endotoxin, into the brain tissue causing vasodilation and neuronal activation.