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Attenuation of arterial baroreflex control of renal sympathetic nerve activity during lidocaine infusion in alpha–chloralose–anesthetized dogso
Author(s) -
YONEDA I.,
NISHIZAWA M.,
BENSON K. T.,
CHAFFEE T. L.,
GOTO H.
Publication year - 1994
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1994.tb03840.x
Subject(s) - baroreflex , lidocaine , medicine , bolus (digestion) , anesthesia , phenylephrine , hemodynamics , blood pressure , heart rate
The purpose of this study was to identify the relationship between sensitivity of arterial baroreflex and plasma concentrations of lidocaine. Using twelve mongrel dogs anesthetized with alpha–chloralose, the left kidney was exposed retroperitoneally, and renal sympathetic nerve activity was recorded continuously. Lidocaine was infused in four different doses: 2 mg– kg BW ‐1 bolus + 100 μg– BW ‐1 . min; 3 mg– kg BW ‐1 bolus+ 200 μg–kg BW ‐1 min; 6 mg–kg BW ‐1 bolus+ 400 μg–kg BW ‐1 min; and 12 mg–kg BW ‐1 + 800 μg–kg BW ‐1 min. Baroreflex depressor and pressor tests using sodium nitroprusside (5–10 μg–kg ‐1 ) and phenylephrine (2–4 μg–kg ‐1 ) were performed before and at 10 min after beginning lidocaine infusion. Plasma lidocaine concentrations determined by high performance liquid chromatography revealed that the steady–state levels were maintained during the baroreflex tests. Baroreflex sensitivity was preserved at plasma concentrations of lidocaine below 5 μg. ml ‐1 . However, cardiac and sympathetic baroreflex sensitivity were significantly attenuated ( P < 0.01) when plasma lidocaine concentrations were well above human convulsion levels (10μg–ml ‐1 ). The results indicate that hemodynamic derangement observed in the lidocaine–induced central nervous system toxicity is, at least in part, due to the attenuated arterial baroreflex.