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Effect of nitrous oxide and volatile anaesthetics on platelet function in man
Author(s) -
NYGÅRD E.,
NAESH O.,
HINDBERG I.,
VALENTIN N.
Publication year - 1994
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1994.tb03834.x
Subject(s) - medicine , nitrous oxide , volatile anesthetic , platelet , anesthesia , pharmacology , isoflurane
Twelve otherwise healthy male volunteers scheduled for arthroscopy of the knee were studied. The influence in vivo of nitrous oxide (N 2 O) per se and the addition of a halogenated volatile anaesthetic (halothane or isoflurane) on ADP–induced platelet aggregation and release of beta–thromboglobulin into plasma was evaluated. All measurements were made before surgery. We found that N 2 O increased platelet aggregation. Adding a halogenated anaesthetic reversed the relative hyperaggregation induced by N a O. The concentrations in plasma of the platelet release product beta thromboglobulin were not influenced by the anaesthetics.