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Myoclonic spasms during treatment with high doses of intravenous morphine in renal failure
Author(s) -
Sjøgren P.,
Dragsted L.,
Christensen C. B.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03809.x
Subject(s) - medicine , morphine , anesthesia
Myoclonic spasms occurred in a patient suffering from renal failure after high doses of continuous intravenous morphine (100 mg/h). The concentrations of morphine, morphine‐6‐glucuronide and morphino‐3‐glucoronide (μmol/l) in plasma were: 1.93, 52.06 and 381.8, and in cerebrospinal fluid were: 1.02, 5.86 and 61.82, respectively. The role of morphine and morphine glucuronides in myoclonic spasms is discussed.