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Comparison of two fentanyl doses to improve epidural anaesthesia with 0.5% bupivacaine for caesarean section
Author(s) -
Halonen P. M.,
Paatero H.,
Hovorka J.,
Haasio J.,
Korttila K.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03808.x
Subject(s) - medicine , fentanyl , anesthesia , bupivacaine , saline , caesarean section , apgar score , analgesic , general anaesthesia , surgery , pregnancy , fetus , biology , genetics
Ninety women undergoing elective caesarean section under epidural anaesthesia were double blindly randomised into three groups to receive either 2 ml of saline or 50 or 100 μg of fentanyl in 2 ml volume added to 0.5% bupivacaine. Both doses of fentanyl intensified the epidural anaesthesia and reduced patient discomfort during the operation. In both fentanyl groups the epidural blockade more often reached the 5th thoracic segment ( P = 0.0258), the patients had significantly less pain ( P = 0.0256), needed less intravenous diazepam medication during the operation ( P = 0.0005) and the operating conditions were better when compared to the saline group ( P = 0.0416). There was no difference between the groups in the condition of the neonates as assessed by the Apgar score and cord blood pH. The postoperative time until treatment for pain was requested by the patients was more than 1 h longer in the fentanyl groups, but there was no difference in the total amount of postoperative analgesics needed during the first 24 h when compared to the saline group. Mild pruritus not requiring treatment was more common in fentanyl groups than in the saline group ( P = 0.0187). The results suggest that 50 μg of fentanyl added to 0.5% bupivacaine increases patient comfort and improves the quality of epidural anaesthesia for caesarean section, and that adding 100 μg does not give further advantage.