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Peripheral antinociceptive effects of morphine after burn injury
Author(s) -
MØINICHE S.,
DAHL J. B.,
KEHLET H.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03795.x
Subject(s) - medicine , morphine , nociception , peripheral , saline , anesthesia , receptor
In a double–blind study, 2 mg of morphine in saline, or saline only, was given subcutaneously into a seconddegree bilateral leg–burn injury in 12 volunteers. Heat–pain thresholds and pressure–pain thresholds were significantly increased by local morphine administration. These results confirm experimental data demonstrating a peripheral antinociceptive effects of opioids in inflamed tissue.