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Effects of halothane on the synthesis of neurotransmitter amino acids in mouse brain
Author(s) -
WATANABE K.,
ARAI T.,
AOKI M.,
MORI H.,
MORI K.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03794.x
Subject(s) - halothane , amino acid , glutamine , glutamate receptor , neurotransmitter , medicine , excitatory amino acid transporter , excitatory postsynaptic potential , inhibitory postsynaptic potential , biochemistry , pharmacology , central nervous system , anesthesia , biology , receptor
The effects of halothane on the synthesis of the three major neuroactive amino acids (θ–aminobutyric acid, aspartate and glutamate) and glutamine, which is closely related metabolically, were investigated in mouse brain using a labelled precursor ([ 13 C]glucose) and a gas chromatography–mass spectrometry system. The ratios of newly synthesised amino acids were increased relative to baseline values when animals were exposed to 1% halothane, and decreased when they were exposed to 2% halothane. These findings suggest that halothane affects the synthesis of neurotransmitter amino acids in a concentration–dependent manner, without discrimination between excitatory and inhibitory amino acids.