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The independent metabolic effects of halo thane and isoflurane anaesthesia
Author(s) -
CARLI F.,
RONZONI G.,
WEBSTER J.,
KHAN K.,
ELIA M.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03787.x
Subject(s) - medicine , isoflurane , anesthesia , halothane , general anaesthesia , hormone , albumin
Twelve healthy, unpremedicated women scheduled for total abdominal hysterectomy were given either isoflurane (n = 6) or halothane (n = 6) anaesthesia. They all general anaesthesia for a period of 3 h, with surgery being carried out only in the last hour. The anaesthesia consisted of thiopentone, pancuronium and a mixture of oxygen–enriched air (Fio 2 = 34%) supplemented with 1 MAC of either isoflurane or halothane. The patients were maintained normothermic, and with an arterial Sao 2 above 95% throughout the period of the study. The following measurements were made before, during and after anaesthesia (with and without surgery): oxygen consumption (Vo 2 ), carbon dioxide production (Vco 2 ); circulating concentrations of various hormones (insulin, growth hormone and Cortisol); various metabolites; selected amino acids and albumin; forearm arterio–venous concentration difference of glucose, lactate, free fatty–acids and selected amino acids (four patients in each group). Whole body Vo 2 decreased significantly by over 20% during anaesthesia (with or without surgery), P < 0.05). Although the circulating concentration of most amino acids showed little or no change during anaesthesia alone, there was a tendency for the flux of most metabolites to decrease, and this persisted during surgery ( P < 0.05). During anaesthesia alone there was a twofold reduction in the plasma Cortisol concentration ( P < 0.05), and a decrease in albumin concentration ( P < 0.01). With the onset of surgery, plasma Cortisol concentration increased rapidly (in association with several other hormones and metabolites) but hypoalbuminemia persisted.