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Increase in lactoferrin and elastase α‐1‐proteinase inhibitor complexes but lack of complement activation and IL‐6 response following thoracic surgery
Author(s) -
WANSCHER M.,
TØNNESEN E.,
ANTONSEN S.,
HOHNDORF K.,
NIELSEN L. K.,
HANSEN G. L.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03772.x
Subject(s) - lactoferrin , medicine , elastase , alpha (finance) , neutrophil elastase , complement system , degranulation , endocrinology , stimulation , immunology , gastroenterology , surgery , inflammation , enzyme , immune system , biochemistry , receptor , construct validity , chemistry , patient satisfaction
Polymorphonuclear neutrophil (PMN) stimulation and degranulation can be mediated by the cytokines and by complement activation. The aim of the present study was to measure TNFa, IL‐lα, IL‐6 and C3d in relation to postoperative increase in lactoferrin and elastase α‐1‐proteinase inhibitor (E α‐l‐PI) levels. Eleven patients undergoing thoracic surgery took part in the study. Blood leucocytes, E α‐l‐PI, lactoferrin and C3d were measured preoperatively, at the end of surgery and postoperatively, at 4 h and on day 1, 2, 3 and 5. TNFa, IL‐lα and IL‐6 were measured preoperatively, at the end of surgery and postoperatively, at 4 h, and on days 1 and 5. The leucocyte count, lactoferrin and E α‐l‐PI levels increased significantly postoperatively ( P < 0.01). There was no significant change in C3d values. Plasma IL‐6 levels were unchanged in the postoperative period. Plasma TNFa and IL‐lα were detectable at low levels in only two and four patients, respectively. Conclusion: The postoperative increase in blood levels of PMN lactoferrin and E α‐l‐PI complexes observed in the present study was not accompanied by complement activation, or increased blood levels of IL‐6.