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Effects of flumazenil during administration of midazolam on pial vessel diameter and regional cerebral blood flow in cats
Author(s) -
KUMANO H.,
SHIMOMURA T.,
FURUYA H.,
YOMOSA H.,
OKUDA T.,
SAKAKI T.,
KURO M.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03766.x
Subject(s) - midazolam , flumazenil , medicine , anesthesia , cerebral blood flow , vasodilation , blood flow , hemodynamics , pentobarbital , antagonist , receptor , sedation
We implanted closed cranial windows in ten cats in order to observe the response of pial vessel diameter by microscopy using fluorescein isothiocyanate‐labeled dextran and regional cerebral blood flow (rCBF) by laser Doppler flowmetry during administration of midazolam and reversal with flumazenil. Midazolam was given at 0.8 mg.kg ‐1 min ‐1 for 10 min and maintained at 0.04 mg‐kg ‐1 min ‐1 for 50 min (total 10 mg‐kg ‐1 ). The diameter of arterioles and venules and rCBF showed no significant change. During the last 10 min of midazolam administration, flumazenil, given at 0.1 mg‐kg ‐1 min ‐1 for 10 min (total 1 mg kg ‐1 ), caused an increase of MAP and rCBF ( P < 0.01) at 5 min after infusion and diameter of larger arterioles (>50 μm) and venules (50–100 μ) were dilated ( P < 0.05). These results indicate that midazolam does not affect the diameter of cerebral arterioles and venules; however, the reversal effects of flumazenil against midazolam are transient vasodilation of larger arterioles accompanied by an elevation of MAP, and an increase in CBF.