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Duration of vecuronium‐induced neuromuscular blockade predicted by dose and onset time
Author(s) -
RøRVIK K.,
HUSBY P.,
GRAMSTAD L.,
VAMNES J. S.,
BøE O. E.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03750.x
Subject(s) - medicine , duration (music) , neuromuscular blockade , onset of action , anesthesia , literature , art
We investigated the adequacy of using dose and onset time as variables to predict the duration of action of vecuronium in patients. The onset time until 95% twitch depression and the duration until 25% twitch recovery were measured for doses ranging from 0.1 to 0.3 mg kg ‐1 . Statistical analyses were performed by simple and multiple regressions. The duration of action was better predicted by dose ( r 2 = 0.61) than by onset time ( r 2 = 0.51). However, the predictability was significantly improved by a multiple regression model of the variables, and the explanatory power was largest when using the square root of duration as the dependent variable ( r 2 = 0.69). We conclude that the duration of neuromuscular blockade after vecuronium can be predicted more accurately by the combined use of dose and onset time than by dose alone.