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The influence of fentanyl and alfentanil on functions of human polymorphonuclear leukocytes in vitro
Author(s) -
KRUMHOLZ W.,
DEMEL C.,
JUNG S.,
MEUTHEN G.,
HEMPELMANN G.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03734.x
Subject(s) - alfentanil , medicine , superoxide , in vitro , fentanyl , myeloperoxidase , hydrogen peroxide , granulocyte , pharmacology , anesthesia , immunology , biochemistry , enzyme , inflammation , biology
Polymorphonuclear leukocytes (PMNL) play an important part in protecting against invading bacteria. It is known that some anaesthetics may impair PMNL functions, thus possibly promoting infection. We investigated the effect of fentanyl and alfentanil on superoxide anion production, hydrogen peroxide generation, and activity of released myeloperoxidase in vitro. However, the two opioids did not have any significant influence on the tested PMNL functions.