Premium
Variability of pipecuronium neuromuscular blockade
Author(s) -
Diefenbach C.,
Mellinghoff H.,
Buzello W.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03698.x
Subject(s) - medicine , neuromuscular blockade , anesthesia , blockade , receptor
The dose‐response relationship and the variability of the time variables in pipecuronium neuromuscular blockade were studied in 29 patients (ASA physical status 3) during halothane anaesthesia. The ED 95 (twitch tension) was determined in 9 patients using the cumulative dose response technique. Another 20 patients received the resulting ED 95 as a single bolus. The mean ED 95 was 35 μg‐kg ‐1 (95% confidence interval: 29–41 μg.kg ‐1 ). Following bolus injection of 1. ED 95 , an 80–100% twitch depression was achieved within 4.6±1.3 min (mean ± s.d.). The duration from end of injection of pipecuronium to 25% twitch recovery, the time from 25% to 75% twitch recovery, and the time from 25% twitch recovery to the train‐of‐four ratio (TOF) returning to 0.7 was 35 ± 14, 37 ± 26, and 63 ± 27 min, respectively. The time from end of injection to TOF = 0.7 varied within a 2‐h range (54–160 min). Thus, the time variables in pipecuronium neuromuscular blockade were as poorly predictable as those reported in the literature on pancuronium, alcuronium and doxacurium.