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Pharmacokinetics of sufentanil in general surgical patients under different conditions of anaesthesia
Author(s) -
Lehmann K. A.,
Sipakis K.,
Gasparini R.,
Peer A.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03696.x
Subject(s) - sufentanil , medicine , enflurane , isoflurane , anesthesia , pharmacokinetics , bolus (digestion) , volume of distribution , halothane , intravenous bolus , plasma concentration , surgery
The pharmacokinetics of sufentanil were studied in 56 surgical patients after an intravenous bolus of 2 μg kg ‐1 , in association with neurolept analgesia or volatile anaesthetics (halothane, enflurane and isoflurane). Plasma concentrations of sufentanil were measured by radioimmunoassay. The kinetics of sufentanil were comparable under neurolept analgesia and under anaesthesia with halothane, enflurane or isoflurane. The overall mean elimination half‐life was 182 min, Vd 85 169 1 and the plasma clearance 910 ml min ‐1 . Except for the isoflurane subgroup, there was no significant correlation between half‐life, the volume of distribution or clearance with age (24–77 years) or body weight (45–95 kg).