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Evaluation of the time course of action of maintenance doses of rocuronium (ORG 9426) under halothane anaesthesia
Author(s) -
KhuenlBrady K. S.,
Pühringer F.,
Koller J.,
Mitterschiffthaler G.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03689.x
Subject(s) - medicine , rocuronium , halothane , anesthesia , muscle relaxation , intubation , onset of action , maintenance dose
The time course of action of rocuronium was compared using three different sizes of maintenance doses after at least three subsequent administrations of the same repeat dose in each patient under halothane anaesthesia. Following endotracheal intubation facilitated with 0.6 mg.kg ‐1 rocuronium (ORG 9426), muscle relaxation was maintained in three groups each consisting of ten patients, using increments of equal repeat doses of either 75 μg‐kg ‐1 , 150 μg‐kg ‐1 or 225 μg.kg ‐1 equivalent to 1/4, 1/2 and 3/4 of the ED 95 of this new compound, respectively. Maintenance doses were administered when the twitch height depression induced by the previous dose returned to 25% of its control value. The clinical duration of the intubating dose averaged 27 ± 7.5 min (mean ± s.d.). The time course of action of the various maintenance doses depended on their size, but not on the number of administrations. The durations of repeat doses averaged 8–9 min, 14–16 min and 19–23 min after the low, medium and high maintenance doses, respectively. No overt cumulative effects were observed.