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The cardiovascular response to ketamine: the effects of clonidine and lignocaine
Author(s) -
Munro H. M.,
Sleigh J. W.,
Paxton L. D.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1993.tb03602.x
Subject(s) - clonidine , medicine , premedication , anesthesia , ketamine , blood pressure , randomized controlled trial , surgery
The effectiveness of clonidine or lignocaine in reducing the cardiostimulatory effects of ketamine was studied. A double‐blind, randomized design was used in three groups of 20 patients each, of ASA grade 1 or 2 presenting for minor elective surgery. The clonidine group received 0.3 mg clonidine orally with the premedication while the lignocaine group received 1.5 mg · kg ‐1 lignocaine prior to induction. The third group formed the controls. All patients were induced with 2 mg · kg ‐1 ketamine intravenously. The systolic blood pressure in the clonidine group was significantly lower than that of both the control and lignocaine groups throughout the study ( P <0.05). It was concluded that clonidine was effective in reducing the hypertensive response to ketamine, whereas lignocaine had no effect.