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Alfentanil infusion in total intravenous anaesthesia (TIVA). Population pharmacokinetics fails to predict plasma concentration of alfentanil
Author(s) -
Jenstrup M.,
Fruergård K.,
Nielsen J.,
Møller A. M.,
WibergJørgensen F.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03576.x
Subject(s) - alfentanil , medicine , pharmacokinetics , anesthesia , propofol , plasma concentration , population , population pharmacokinetics , pharmacology , environmental health
In order to evaluate the ability to predict plasma concentrations from population‐corrected pharmacokinetics, a prospective study comprising 14 women admitted for elective hysterectomy was done. Alfentanil was given in combination with propofol in a total intravenous anaesthesia technique. The predicted median alfentanil concentration (289(256–363) ng ml ‐1 ) was significantly lower than the measured median plasma concentration of 368(168–666) ng ml ‐1 ). In conclusion, population‐based pharmacokinetics were found not to be accurate as they underestimate plasma concentrations of alfentanil.