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Effects of verapamil on histamine‐induced changes in lung mechanics
Author(s) -
Mima M.,
Taguchi H.,
Oya M.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03542.x
Subject(s) - verapamil , medicine , histamine , anesthesia , airway resistance , isotonic , airway , bronchoconstriction , sodium , pharmacology , calcium , chemistry , organic chemistry
The effects of verapamil on airway resistance and total thoracic compliance were studied in 15 rabbits with histamine‐induced changes in lung mechanics. The animals, after being tracheotomized under anaesthesia, were subjected to mechanical ventilation in a time‐cycled, volume‐limited mode. Airway pressure and gas flow signals measured by a pneumotachograph and integrated for volume, were registered on a recorder. Each animal was given histamine hydrochloride in an isotonic solution of sodium chloride at a rate of 0.05 μg · kg ‐1 · min ‐1 through a peripheral venous line. Verapamil was infused intravenously in an isotonic solution of sodium chloride at a rate of 20 μg · kg ‐1 · min ‐1 after the initiation of histamine. Verapamil reduced the histamine‐induced increase in airway resistance by 20% at 20 min after the start of administration.