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Adrenaline absorption: effect of pH in mepivacaine and bupivacaine solutions. A clinical study during halothane anesthesia
Author(s) -
Ueda W.,
Hirakawa M.,
Mori K.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03539.x
Subject(s) - mepivacaine , bupivacaine , medicine , anesthesia , absorption (acoustics) , epinephrine , halothane , physics , acoustics
The effect of the pH of the solution on the rate of absorption into the blood stream of locally‐injected adrenaline using an adrenaline solution mixed with either mepivacaine or bupivacaine was investigated. Forty patients undergoing elective craniotomy received one of the following five solutions for subcutaneous and subgaleaic injection in the dose 0.5 ml/kg: 1) mepivacaine‐adrenaline (pH = 6.1), 2) mepivacaine‐adrenaline (pH = 7.5), 3) bupivacaine‐adrenaline (pH = 6.1), 4) bupivacaine‐adrenaline (pH = 7.4), or 5) adrenaline (pH = 6.1). Both mepivacaine and bupivacaine added to the adrenaline solution increased the plasma concentration of adrenaline. Alkalinization attenuated the peak concentration of adrenaline in the case of a mepivacaine‐adrenaline solution, but not in the case of a bupivacaine‐adrenaline solution.