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Single‐dose oral omeprazole for reduction of gastric residual acidity in adults for outpatient surgery
Author(s) -
Haskins D. A.,
Jahr J. S.,
Texidor M.,
Ramadhyani U.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03509.x
Subject(s) - medicine , omeprazole , residual volume , dose , anesthesia , outpatient clinic , placebo , gastric acid , gastric secretion , gastroenterology , surgery , stomach , lung volumes , alternative medicine , pathology , lung
Omeprazole is a substituted benzimidazole that causes dose‐dependent intracellular inhibition of gastric acid secretion in humans. This double‐blind study examined the effect of omeprazole in decreasing gastric acidity and gastric residual volume in outpatient adults. Unpremedicated outpatients, ASA I–III, 18 years or older (n=17), were randomly assigned to receive omeprazole 80 mg, or placebo by mouth the night before scheduled elective outpatient surgery. The patients were fasted for 8 h prior to surgery. After the patient was anesthetized, an orogastric tube was inserted with proper placement verified by auscultation for gastric sounds. Gastric residual contents were withdrawn into a Luken's trap, and pH was then determined and gastric volume indexed to weight (ml ˙ kg ‐1 ). Data were analyzed by a t ‐test, with P <0.05 considered statistically significant. Patient characteristics of both groups were similar. There was a statistically significant difference between the two groups for pH ( P =0.02), but not between the two groups for gastric volume indexed to weight ( P =0.07).