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The effects of brain temperature on temporary global ischaemia in rat brain. A 31‐phosphorous NMR spectroscopy study
Author(s) -
Haraldseth O.,
Grønås T.,
Southon T.,
Thommessen L.,
Borchgrevink G.,
Jynge P.,
Gisvold S. E.,
Unsgård G.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03487.x
Subject(s) - phosphocreatine , medicine , hypothermia , intracellular ph , ischemia , intracellular , anesthesia , hyperthermia , nuclear magnetic resonance spectroscopy , brain ischemia , endocrinology , nuclear magnetic resonance , biochemistry , energy metabolism , chemistry , physics
31‐Phosporous magnetic resonance spectroscopy was used in a rat model of 10 min severe incomplete forebrain ischaemia (2‐vessel occlusion with hypotension) to assess the effect of mild brain hypo‐ and hyperthermia (± 2°C) on intracellular pH and high energy phosphates. In three experimental groups intracerebral temperature was maintained at levels of 34, 36 and 38°C during ischaemia and early reperfusion. The steady level of intracellular pH during ischaemia was 6.63, 6.58 and 6.53 in the 34, 36, and 38°C groups, respectively. The rate of initial recovery of intracellular pH in reperfusion was 0.046 ±0.012 pH units per min (± s.d.) in the 36°C group compared to 0.056 ±0.010 (± s.d., P <0.05) in the 34°C group and 0.032 ± 0.009 (± s.d., P <0.01) in the 38°C group. The recovery in early reperfusion of phosphocreatine and ATP was slower in the 38°C group compared to the other groups. The findings were consistent with recent studies, suggesting that even mild hypothermia may afford protection to the ischaemic brain, and furthermore indicate that mild hyperthermia as fever or even subfebrility may be deleterious for the outcome in stroke patients.