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Prophylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins
Author(s) -
Claeys M. A.,
Camu F.,
Maes V.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03463.x
Subject(s) - medicine , diclofenac , placebo , anesthesia , orthopedic surgery , bolus (digestion) , piroxicam , surgery , alternative medicine , pathology
The influence of diclofenac, given by continuous i.v. infusion starting preoperatively, on postoperative pain and inflammation was assessed in a double‐blind, randomized, placebo‐controlled study in 40 patients scheduled for major orthopedic surgery. Starting 30 min before induction the patients received either diclofenac (0.35 mg.kg ‐1 bolus followed by a constant‐rate infusion of 90 μ.min ‐1 ) or placebo for 24 h. The pain intensity (VAS) and the amount of rescue narcotic (piritramide on demand) were significantly lower in the diclofenac group from 4 and 6 h postsurgery, respectively, till end of infusion. Acute phase proteins used as inflammation markers (C‐reactive protein, α 1 ‐chymotrypsin, α 1 ‐acid glycoprotein, haptoglobin and coeruloplasmin) showed similar variations in both groups for 24 h. The diclofenac treatment had no influence on hematological and coagulation profiles, nor on muscle and liver enzymes in comparison with placebo. Both patients and observer rated the diclofenac treatment as significantly superior to the placebo treatment.