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High frequency of cough after intravenous bolus injection of Ketogan® (ketobemidone + N, N‐dimethyl‐3,3‐diphenyl‐1‐methylallylamine chloride) for postoperative pain relief
Author(s) -
Karlsten R.,
Hartvig P.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03450.x
Subject(s) - medicine , anesthesia , bolus (digestion) , opioid , surgery , bupivacaine , receptor
The frequency of cough 15–45 s after intravenous administration of a low dose of the opioid receptor agonist ketobemidone given for postoperative pain relief was assessed in 121 patients undergoing gynaecological or obstetrical operations. In patients subjected to caesarian section under spinal anaesthesia using bupivacaine, the frequency of an early cough reaction was 50.7%, whereas in patients previously exposed to opioids during the surgical procedure the frequency was 11.1%. This side‐effect of ketobemidone has not been reported before.