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Effects of low‐dose propofol administration on central respiratory drive, gas exchanges and respiratory pattern
Author(s) -
Rosa G.,
Conti G.,
Orsi P.,
D'Alessandro F.,
Rosa I. La,
Giugno G. Di,
Gasparetto A.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03438.x
Subject(s) - medicine , propofol , anesthesia , capnography , respiratory system , respiratory rate , sedation , tidal volume , sedative , hypnotic , respiratory center , respiratory minute volume , blood pressure , heart rate
The effects of sedative‐hypnotic doses of propofol on respiratory drive and pattern have not yet been extensively described. Repeated small boluses of propofol (0.6–0.3 mg ?˙ k ‐1 ) were administered to ten ASA I patients undergoing carpal tunnel release using regional anaesthesia. Airway pressure, capnography and pneumotachography were continuously recorded. With respect to basal values, no significant variations of respiratory rate, minute volume, tidal volume, inspiratory and expiratory time, total expiratory cycle, Ti/Ttot, TV/Ti, P0.1, Etco 2 and blood gas analysis were observed. Low doses of propofol, to maintain conscious sedation or light sleep, have not been shown to cause respiratory depression.