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In vivo potentiation of atracurium neuromuscular blockade by nimodipine in rabbits
Author(s) -
GómezIglesias E.,
García E.,
Suarez E.,
Martínez R.,
RodríguezSasiaín J. M.,
Calvo R.
Publication year - 1992
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1992.tb03424.x
Subject(s) - nimodipine , medicine , long term potentiation , anesthesia , neuromuscular blockade , neuromuscular blocking agents , blockade , pharmacology , calcium , receptor
The interaction between nimodipine, a calcium channel blocker, used for the treatment of subarachnoid haemorrhage, and atracurium, was studied in rabbits. An intravenous dose of 0.1 mg±kg ‐1 of nimodipine given over 3 min caused a potentiation of the neuromuscular blocking action of atracurium (administered at an infusion rate of 7.5 μg±kg ‐1 ±min ‐1 ), measured on the indirectly stimulated tibialis‐anterior muscle of the animal. (ED 50 ) inf and (ED 95 ) inf were significantly reduced (30.7% and 23.3%) in nimodipine‐treated animals ( P <0.05 and P <0.02, respectively). No changes were observed in recovery rate.