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Manipulation of the immunoinflammatory reaction in clinical sepsis
Author(s) -
Sjölin J.
Publication year - 1993
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb05068.x
Subject(s) - medicine , sepsis , septic shock , intensive care medicine , pathophysiology , disease , antibiotics , presentation (obstetrics) , severe sepsis , shock (circulatory) , gram staining , antibiotic therapy , stage (stratigraphy) , inotrope , immunology , surgery , microbiology and biotechnology , paleontology , biology
For many years patients with sepsis and septic shock have been treated with antibiotics, fluids, surgery (if indicated) and, in the more severe cases, inotropic and ventilatory support. During recent years there has been an intensive development of new treatments based on increased knowledge of the pathophysiology. This presentation will focus on treatments modulating the immunoinflammatory response, which are either available in clinical practice today or which will be available in the near future. It is concluded that optimal therapy depends on the stage of the septic disease as well as the gram stain of the causative bacteria.