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Extracorporeal carbon dioxide removal performed with surface‐heparinized equipment in patients with ARDS
Author(s) -
Bindslev L.,
Böhm C.,
Jolin A.,
Jonzon K. Hambraeus,
Olsson P.,
Ryniak S.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03409.x
Subject(s) - medicine , ards , extracorporeal , heparin , extracorporeal circulation , extracorporeal membrane oxygenation , anesthesia , acute respiratory distress , lung , intensive care medicine , surgery
To avoid the drawbacks of systemic anticoagulation during prolonged extracorporeal circulation in patients with adult respiratory distress syndrome (ARDS) a heparinization technique has been developed by which partially degraded heparin can be covalently end‐point attached to the surface of the equipment constituting the extracorporeal circuit (Carmeda Bio‐Active Surface, CBAS) thereby localizing the anticoagulatory effect. Since 1986 we have used extracorporeal circuits and membrane lungs coated with the CBAS for extracorporeal lung assistance (ECLA) in 14 patients suffering from ARDS. The patients were on ECLA for 3 to 55 days with a survival rate of 43%. Our experience so far is that by using equipment coated with CBAS it is possible to perform long‐term extracorporeal circulation with a minimum of intravenously administered heparin, thus avoiding the risk of major coagulation defects.