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Prevention of endotoxin‐induced increase of cerebral oxygen consumption in dogs by propranolol pretreatment
Author(s) -
Westerlind A.,
Larsson L. E.,
Häggendal J.,
EkströmJodal B.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03383.x
Subject(s) - medicine , propranolol , oxygen , anesthesia , pharmacology , organic chemistry , chemistry
Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRo 2 ) were studied in experimental endotoxic shock in dogs. Eight animals were pretreated with a beta‐adrenoceptor blocking agent, propranolol (PPL), per as 12 mg/kg once a day for 7 days. Ten animals served as controls. After an intravenous injection of endotoxin, 1 mg/kg, CBF decreased in both groups, with no significant differences between the groups. CMRo 2 , increased in the control animals by about 18% from the baseline value both 1 and 2 h after the injection of endotoxin. CMRo 2 in the PPL‐pretreated animals was unchanged after endotoxin. The CMRo 2 ‐reactions to endotoxin in control and PPL animals were significantly different after both 1 and 2 h ( P <0.05). The present results indicate that the increase in CMRo 2 following intravenous endotoxin is mediated via beta‐adrenoceptors.