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Decreased expression of class II major histocompatibility complex (MHC) molecules on monocytes is found in open‐heart surgery related immunosuppression
Author(s) -
RyhÄaUnen P.,
Surcel H.M.,
Ilonen J.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03327.x
Subject(s) - major histocompatibility complex , medicine , immunosuppression , monocyte , immunology , mhc class ii , peripheral blood mononuclear cell , human leukocyte antigen , lymphocyte , hla dr , histocompatibility , immune system , antigen , biology , genetics , in vitro
The expression of class II major histocompatibility complex (MHC) molecules on monocytes and the relative proportion of immunoregulatory lymphocyte subpopulations were studied from the blood of eight patients undergoing a cardiac operation. The aim of the study was to reveal mechanisms responsible for depression of cellular immunity and B‐lymphocyte activation associated with open‐heart surgery. A decreased staining of HLA‐DR and even more of HLA‐DQ class II MHC molecules was found on the monocyte surface in samples taken 2 and 7 days after operation when compared to preoperative values. The relative proportion of monocytes in mononuclear cells increased after surgery, but within lymphocyte subpopulations only a decrease in total T cells and an increased number of activated (HLA‐DR positive) T cells were found, whereas the rations between various T cells subsets remained relatively stable.