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Model‐based adaptive closed‐loop feedback control of atracurium‐induced neuromuscular blockade
Author(s) -
Olkkola K. T.,
Schwilden H.,
Apffelstaedt C.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03321.x
Subject(s) - neuromuscular blockade , medicine , atracurium besilate , pharmacodynamics , blockade , population , control theory (sociology) , dosing , anesthesia , pharmacokinetics , control (management) , pharmacology , computer science , receptor , environmental health , artificial intelligence
Closed‐loop control of atracurium‐induced neuromuscular blockade by a model‐based adaptive feedback algorithm is described. Mean offsets (± s.d.) from setpoints at 50, 70 and 90% neuromuscular blocks using the Relaxograph® were 1.1 ± 1.3, 0.2 ± 0.7 and 0.1 ± 0.4%, respectively. Correspondingly, the mean steady‐state rates of infusion of atracurium were 0.20 ± 0.06, 0.25 ± 0.03 and 0.39 ± 0.10 mg ‐ kg ‐1 ‐ h ‐1 . The described controller provides reasonable control of atracurium dosing at different degrees of neuromuscular blockade. It gives a solution to the problem of adapting pharmacokinetic and pharmacodynamic data to individuals when using population mean data as starting values for drug therapy.