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Comparison of the haemodynamic effects of pipecuronium and pancuronium during fentanyl anaesthesia
Author(s) -
Stanley J. C.,
Carson I. W.,
Gibson F. M.,
McMurray T. J.,
Elliott P.,
Lyons S. M.,
Mirakhur R. K.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03285.x
Subject(s) - medicine , fentanyl , anesthesia , heart rate , hemodynamics , blood pressure , bradycardia , mean arterial pressure
Haemodynamic variables were measured following administration of pipecuronium 70 μgkg‐ and pancuronium 90 μgkg ‐1 (approximately equivalent to 1.5 x ED 95 ) in patients anaesthetised with fentanyl 50 μgkg ‐1 and scheduled to undergo coronary artery bypass grafting. There were significant increases in heart rate (22%), mean arterial pressure (10%), cardiac index (16%), and the rate pressure product (35%) following administration of pancuronium. The absolute values of these parameters were, however, within acceptable clinical limits. Administration of pipecuronium produced minimal and insignificant changes in these parameters. Other measured or derived indices showed only small changes with both agents and these were generally insignificant. There were no incidences of significant bradycardia following pipecuronium administration. The results from the present study suggest that pipecuronium would have advantages for use in patients with significant cardiovascular disease.