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Comparison of standard and high‐dose adrenaline in the resuscitation of asystole and electromechanical dissociation
Author(s) -
Lindner K. H.,
Ahnefeld F. W.,
Prengel A. W.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03283.x
Subject(s) - medicine , asystole , resuscitation , epinephrine , anesthesia , advanced cardiac life support , blood pressure , cardiopulmonary resuscitation
Sixty‐eight adults with cardiac arrest (asystole and electromechanical dissociation) were randomly allocated for treatment with standard (1 mg) or high‐dose epinephrine (5 mg). If the first dose of adrenaline 11 or 5 mg) failed, standardized advanced life‐support was applied in all cases. High‐dose adrenaline was associated with higher initial resuscitation success rates (16 of 28) than standard‐dose adrenaline (6 of 40), whereas hospital discharge rates were not significantly different between the groups. Blood pressure was significantly higher in the high‐dose adrenaline group in comparison to the standard dose at 1 and 5 min after resuscitation. Although high‐dose adrenaline appears to improve cardiac resuscitation success, the duration of global cerebral ischaemia seems to determine the ultimate outcome.