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Halothane enhances the binding of diazepam to synaptic membranes from rat cerebral cortex
Author(s) -
Nakao S.,
Arai T.,
Murakawa M.,
Mori K.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03274.x
Subject(s) - halothane , diazepam , medicine , cerebral cortex , membrane , synaptic membrane , anesthesia , pharmacology , neuroscience , biophysics , receptor , biochemistry , chemistry , biology
The effects of halothane on diazepam binding to the rat cerebral synaptic membranes were investigated. Halothane at the concentrations of 0.63, 1.3 and 4.1 mmol/1 increased the binding by 12, 23 and 33%, respectively, compared to the control in the absence of halothane. The increments were dependent on the presence of Cl. The findings indicate that halothane and diazepam have an interaction at receptor level.