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Breath‐by‐breath measurement of oxygen consumption and F io 2 ‐F eo 2 with increased oxygen demand
Author(s) -
Davies R. E.,
Noe F. E.,
Whitty A. J.,
Busby M. G.,
Davies K. R.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03273.x
Subject(s) - oxidative phosphorylation , oxygen , medicine , respiratory system , respiration , carbon dioxide , phosphorylation , anesthesia , pharmacology , biochemistry , chemistry , anatomy , organic chemistry
Continuous on‐line breath‐by‐breath measurement of pulmonary gas exchange was used to monitor the increase in oxygen uptake (Vo 2 ) and carbon dioxide excretion (Vco 2 ) induced by the oxidative phosphorylation uncoupling agent 2, 4‐dinitrophenol (DNP) in 10 dogs. With incremental doses of DNP totaling 5 mg/kg, the continuously monitored Vo 2 increased within 2–3 min after the first injection of the drug. Vco 2 showed a similar response 4–6 min after the first injection. Temperature increase due to the pharmacological oxidative phosphorylation uncoupling required 20–30 min for a discernible change at this dose. This study also demonstrated a modified and compromised response to the drug in dogs where oxygen delivery was limited by mechanical ventilation.