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A comparison between morphine, meperidine and ketobemidone in continuous intravenous infusion for postoperative relief
Author(s) -
ÖHQVIST G.,
HALLIN R.,
GELINDER S.,
LANG H.,
SAMUELSON S.
Publication year - 1991
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1991.tb03238.x
Subject(s) - medicine , anesthesia , shivering , nausea , vomiting , morphine , continuous infusion , heart rate , surgery , blood pressure , radiology
Morphine, meperidine and ketobemidone used in continuous i. v. infusion for postoperative pain relief were compared in a double‐blind, controlled, prospective study in 81 consecutive consenting adult patients after open‐heart surgery, with permission from the hospital ethics committee. During the first postoperative period, the infusion rates were fixed. Later on, when the infusion rate could be regulated according to individual patient needs, the variation in infusion rate was large, in accordance with earlier studies. No significant differences were demonstrated between the three analgesics with respect to efficacy of analgesia or side effects like shivering, nausea or vomiting. Respiratory depression following extubation was not observed. During shivering, there was a significant increase in the arterio‐mixed venous difference of oxygen in all groups. The amounts of opioids used were relatively small compared to amounts used in patients following abdominal surgery. When interviewed some days after surgery, 18/74 patients remembered moderate pain and 11 severe pain during the stay in the ICU.