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The effect of the benzodiazepine antagonist flumazenil on regional cerebral blood flow in human volunteers
Author(s) -
Wolff J.,
Friberg L.,
Jensen J.,
Hansen P. B.,
Andersen A. R.,
Lassen N. A.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03160.x
Subject(s) - flumazenil , medicine , cerebral blood flow , anesthesia , benzodiazepine , antagonist , hemodynamics , placebo , blood flow , blood pressure , cardiology , pathology , receptor , alternative medicine
The influence of the benzodiazepine antagonist flumazenil on regional cerebral blood flow (rCBF) was investigated in ten healthy, alert volunteers. The design was a randomized, placebo‐controlled, double‐blind, cross‐over study. rCBF was measured by 133‐Xe inhalation and single photon emission computerized tomography, SPECT, immediately before, and 5 and 35 min after intravenous injection of flumazenil 1.0 mg or placebo. In addition, mean arterial blood pressure and Paco 2 were measured. There were no significant differences in the mean arterial blood pressures or Paco 2 . rCBF were analysed for changes in various regions of interest (RoI). No alterations were found either in the global CBF or in rCBF in RoI after flumazenil injection. The results showed that a clinically active dose of flumazenil did not directly affect the cerebral circulation in the normal brain and indicated absence of significant intrinsic activity of the drug.