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Pulmonary clearance of 99mTc‐DTPA during halothane anaesthesia
Author(s) -
Wollmer P.,
Schairer W.,
Bos J. A. H.,
Barker W.,
Krenning E. P.,
Lachmann B.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03147.x
Subject(s) - halothane , medicine , anesthesia , lung , clearance rate , inhalation , pulmonary surfactant , oxygen , chemistry , biochemistry , organic chemistry
We studied the integrity of the alveolo‐capillary barrier during different forms of anaesthesia by measuring the pulmonary clearance of inhaled 99m Tc‐DTPA. We studied four groups of rabbits. Groups I and II were anaesthetized with nembuthal only and the fractional concentration of inspired oxygen (F 1 O 2 ) was 0.30 and 1.00, respectively. Groups III and IV were anaesthetized with 1% halothane and F 1 O 2 was 0.30 and 0.99, respectively. 99m Tc‐DTPA was administered as a fine aerosol and the clearance of the tracer from the lungs was subsequently measured with a gamma camera. The mean half‐life of the tracer in the lungs in Groups I‐IV was 60, 58, 59 and 26 min, respectively. The rapid pulmonary clearance of 99m Tc‐DTPA in Group IV indicates that halothane in combination with high oxygen concentration increases the permeability of the alveolo‐capillary barrier. This may be due to effects on the pulmonary surfactant system and/or the alveolar epithelium.