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Changes of blood pressure and cerebral arterio‐venous oxygen content differences (AVDo 2 ) with and without bupivacaine scalp infiltration during craniotomy
Author(s) -
Engberg M.,
Melsen N. C.,
Herlevsen P.,
Haraldsted V.,
Cold G. E.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03100.x
Subject(s) - medicine , bupivacaine , anesthesia , scalp , craniotomy , saline , infiltration (hvac) , blood pressure , surgery , physics , thermodynamics
In 20 patients subjected to craniotomy for supratentorial cerebral tumours, the effect of scalp infiltration with bupivacaine before incision was evaluated by measuring mean arterial blood pressure (MABP) and cerebral arterio‐venous oxygen content differences (AVDo 2 ) repeatedly during the operation. All patients were given halothane 0.5% anaesthesia. Ten patients were given bupivacaine 0.25% and ten patients were given normal saline for scalp infiltration prior to incision. The study was performed in a double‐blind randomized fashion. Significantly higher values of MABP ( P <0.0005) after incision were found in the saline group compared to the bupivacaine group. Significantly lower values of AVDo 2 ( P <0.0005) after incision were seen in the saline group compared to the bupivacaine group. The results indicate that the increase in MAPB associated with a decrease in AVDo 2 , suggesting an increase in CBF and cerebral hyperperfusion, is reduced by using bupivacaine scalp infiltration prior to incision.