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Reduced expression of mannose‐specific receptors on murine peripheral blood polymorphonuclear leukocytes following prolonged anaesthesia with different inhalation agents
Author(s) -
Bardosi L.,
Bardosi A.,
Hendrys M.,
Gabius H.J.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03087.x
Subject(s) - medicine , isoflurane , receptor , inhalation , halothane , enflurane , phagocytosis , lectin , pharmacology , mannose , receptor expression , immunology , mannose receptor , anesthesia , macrophage , in vitro , biology , biochemistry
Inhalation anaesthetic agents are known to depress phagocytic functions such as mobilization, attachment, chemotactic motility, engulfment and intracellular killing. Mannose‐specific sugar receptors on the surface of leukocytes are involved in a series of phagocytosis‐related activities. To investigate the effect of anaesthesia on the expression of this type of sugar receptor, mice were anaesthetized with halothane, enflurane and isoflurane. The presence of mannose‐binding receptors on peripheral blood polymorphonuclear leukocytes was examined glycocytochemically using the biotinylated neoglycoprotein mannosylated bovine serum albumin. Prolonged administration of inhalation anaesthetic agents, especially halothane, markedly depressed expression of mannose‐specific receptors. This reduction may possibly contribute to postoperative immunodepression, resulting from the impaired cellular interaction which is involved in the phagocytic function of granulocytes.