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Comparison of the effects of fentanyl on respiratory mechanics under propofol or thiopental anaesthesia
Author(s) -
Cigarini I.,
Bonnet F.,
Lorino A. M.,
Harf A.,
Desmonts J. M.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03080.x
Subject(s) - medicine , propofol , fentanyl , anesthesia , respiratory physiology , respiratory system
Twenty patients were randomly anaesthetized with either thiopental 5 mg/kg followed by a 15 mg/kg/h continuous infusion, or propofol 2.5 mg/kg followed by a 9 mg/kg/h continuous infusion, paralysed with vecuronium 0.1 mg/kg, intubated and ventilated with nitrous oxide 50% in oxygen. Fifteen minutes after induction, fentanyl 5 μg/kg was injected. Inspiratory tracheal pressure (PT), gas flow (V) and volume (V) were continuously measured while the lungs were inflated with a constant inspiratory flow ventilator. Respiratory compliance (Crs) and resistance (Rrs) were calculated from the regression of PT on V. In both groups Crs decreased following anaesthesia. Fentanyl injection elicited an increase in Rrs (from 1.04 ± 0.70 to 1.63 ± 0.92 kPa · 1 ‐t · s) and a further decrease in Crs (from 0.55 ± 0.30 to 0.42.± 0.10 1 · kPa ‐1 ) in the thiopental group but not in the propofol group (Rrs: 1.26 ± 0.69 to 1.08.± 0.44 kPa · 1 ‐1 · s, Crs: 0.49 ± 0.11 to 0.48 ± 0.13 1 · kPa ‐1 ). These results suggest that the dose of propofol administered in this study may prevent fentanyl‐induced bronchoconstriction.