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The interaction of neuromuscular relaxants with rabbit lung muscarinic receptors
Author(s) -
Sugai Y.,
Sugai K.,
Mishima M.,
Okuda C.,
Miyazaki M.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03079.x
Subject(s) - medicine , muscarinic acetylcholine receptor , rabbit (cipher) , pharmacology , receptor , anesthesia , neuroscience , statistics , mathematics , biology
The interaction of muscle relaxants with airway muscarinic receptors of rabbit lung was investigated in vitro by the [ 3 H]QNB binding technique. Pancuronium, vecuronium, alcuronium and succinyl choline chloride (SCC) inhibited the binding of [ 3 H]QNB to rabbit lung muscarinic receptors in a dose‐dependent manner. The values of IC 50 (the concentration giving 50% inhibition) of pancuronium, vecuronium, alcuronium and SCC were 1.54 times 10 ‐5 , 2.52 times 10 ‐5 , 8.40 times 10 ‐5 , and 4.00 times 10 ‐3 moll respectively. As the values of Kd increased with minimal change in the value of Bmax, while not influencing the number of receptors, these muscle relaxants had an inhibitory action on the affinity of muscarinic receptors to [ 3 H]QNB in the order: pancuronium ≥ vecuronium > alcuronium > SCC. Applying IC 50 values to human conditions, clinical doses of these muscarinic relaxants are unlikely to exhibit any significant vagolytic action in lung tissue.