Premium
Effects of intravenous administration of local anesthetics on the renal sympathetic nerve activity during nitrous oxide and nitrous oxide‐halothane anesthesia in the cat
Author(s) -
NISHIKAWA K.,
FUKUDA T.,
YUKIOKA H.,
FUJIMORI M.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03076.x
Subject(s) - medicine , lidocaine , halothane , anesthesia , baroreceptor , nitrous oxide , cats , bupivacaine , heart rate , blood pressure , thiamylal
The effects of subseizure doses of lidocaine and bupivacaine administered intravenously (i.v.) on mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were studied in cats anesthetized with nitrous oxide (N 2 O)‐O 2 and N 2 O‐O 2 ‐halothane (1 %). In cats anesthetized with N 2 O‐O 2 , MAP decreased briefly (P<0.01) and then returned to the initial level within a minute after the i.v. injection of lidocaine (5 mg/kg, 10 mg/kg). RSNA increased at first and then decreased slightly. In cats with denervated baroreceptors, the change in RSNA after lidocaine 5 mg/kg i.v. was similar to that in cats with intact baroreceptors. In contrast, MAP, HR and RSNA decreased significantly (P<0.01) after i.v. injection of lidocaine during N 2 O‐O 2 ‐halothane anesthesia. The effects of bupivacaine on RSNA were similar to those of lidocaine. It is concluded that cardiovascular depression following intravenous local anesthetics during N 2 O‐O 2 ‐halothane anesthesia may be caused by both a decreased sympathetic activity and a direct depressant effect on the myocardium.