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Ventilatory effects of almitrine bismesilate in dogs breathing normoxic, hyperoxic and hypoxic mixtures
Author(s) -
Gaudy J. H.,
Sicard J. F.,
Gateau O.
Publication year - 1990
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1990.tb03049.x
Subject(s) - hyperoxia , medicine , hypoxia (environmental) , anesthesia , ventilation (architecture) , oxygenation , tidal volume , respiratory minute volume , halothane , respiratory system , oxygen , lung , chemistry , mechanical engineering , organic chemistry , engineering
The ventilatory effects of 1 mg · kg ‐1 i.v almitrine were studied in five dogs anaesthetized with halothane 2% under conditions of normoxia, hyperoxia and hypoxia Ventilation (minute ventilation, respiratory frequency, tidal volume, duration of inspiration and expiration, ratio TI/Ttot and VT/TI), Pao 2 , Paco 2 , pHa, systemic arterial pressure and heart rate were measured in air before and following almitrine; in air, after inhalation of pure oxygen and after almitrine in hyperoxia; in air, during hypoxia with Fio 2 progressively decreased from 0.21 to 0.12 and after almitrine in hypoxia (Fro 2 =0.12). Halothane decreased ventilatory response to hypoxia. Almitrine stimulated ventilation irrespective of the level of oxygenation and restored the ventilatory response to hypoxia. Hyperoxia did not suppress ventilatory action of almitrine whose action is probably partly central. Hypoxia and almitrine did not induce major systemic haemodynamic modification.