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Volume‐controlled ventilation with superimposed high frequency ventilation during expiration in healthy and surfactant‐depleted pig lungs
Author(s) -
LACHMANN B.,
SCHAIRER W.,
HAFNER M.,
ARMBRUSTER S.,
JONSON B.
Publication year - 1989
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1989.tb03015.x
Subject(s) - medicine , expiration , ventilation (architecture) , oxygenation , dead space , pulmonary surfactant , anesthesia , mean airway pressure , airway , positive end expiratory pressure , mechanical ventilation , high frequency ventilation , tidal volume , respiratory system , mechanical engineering , physics , engineering , thermodynamics
In the healthy and surfactant‐depleted lungs of five pigs the influence of different forms of high frequency ventilation superimposed on conventional mechanical ventilation during the expiratory phase of the ventilatory cycle (SHFVE) on gas exchange and cardiocirculatory parameters was investigated. Subsequently the effects of end‐expiratory flushing (EF), i.e. cleaning the large airways and connecting tubes from the ventilator free from end‐expiratory CO 2 , with a volume greater than the dead space of the large airways and connecting tubes was investigated. SHFVE and EF resulted in a significant improvement in CO 2 elimination in both healthy and surfactant‐depleted lungs. Furthermore, in stiff lungs, at a certain level of oxygenation and CO 2 elimination, SHFVE produced the lowest peak and mean airway pressure without any additional depression of cardiocirculatory parameters.